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A new model study presented at this year’s annual meeting of the European Association for Diabetes Research (EASD), which took place online this year, suggests that the average person with type 1 diabetes (T1DM) in the UK will live almost eight years less today than the average person in the general population without diabetes, while those with type 2 diabetes (T2DM) will live almost 2 years less. The study was led by modeling expert Mike Stedman, Res Consortium, Andover, UK, and Dr. Adrian Heald, University of Manchester, UK, and colleagues.
The authors used various data for their analysis. The UK’s National Diabetes Audit (NDA) published the standardized all-cause mortality rate for people with T1DM and T2DM as well as information on age and gender for the period 2015-16. The Office for National Statistics (ONS) published the actual death rates of the general population for each age and gender for the period 2015-17.
In their model, the authors applied the relative NDA mortality rates to the population rates for each age / sex and then calculated future life expectancy for T1DM / T2DM / non-DM populations. The difference between the total life expectancy for the total reported populations by age and sex of T1DM and T2DM and an equivalent population with non-DM resulted in the total number of “years of life lost” (LLY).
The researchers took data from 6,165 general practitioners to assist 41.3 million people, of whom 217,000 were on the T1DM registry and 2.50 million were on the T2DM registry. In the model, the “average” person with T1DM (age 42.8 years) has a life expectancy of 32.6 years (up to 75.4 years) compared to 40.2 years (up to 83.0 years) in the non- diabetic population of the appropriate age, corresponding to a mean LLY of 7.6 for the average person with T1DM.
The model showed that the “average” person with T2DM (65.4 years) had a life expectancy of 18.6 years (up to 84.0 years) compared to 20.3 years (up to 85.7 years) for the equivalent non-diabetic population, equivalent to an LLY of 1.7 years / average person with T2DM.
Compared to the average LLY for men, the average LLY / person was 21% higher for women with T1DM and 45% higher for women with T2DM.
The authors add that the NDA reports that 70% of patients with T1DM and 33% of patients with T2DM had glycated hemoglobin (HbA1c) (a measure of blood sugar control) greater than 58 mmol / mol, and therefore at higher risk for bad illness had results. By assigning the total LLY to the future life expectancy of both the T1DM and T2DM risk groups, the model shows that a person with both types of diabetes can shorten their life by 100 days every year with HbA1c> 58 mmol / mol. The authors say, “Knowing this can act as an incentive for clinicians to ensure that all people are receiving the best therapy to keep their blood glucose levels within target and that these people are more concerned with their therapy and lifestyle recommendations.” “
The authors mention some limitations of their study, namely the use of mortality data at the national level rather than data at the general practitioner level. Other factors such as smoking, inactivity, being overweight, high blood pressure, and taking statins are also likely to contribute. These will be the subject of a future full analysis with data at the general practice level. However, the authors say that HbA1c levels are likely to remain a strong independent determinant of mortality.
They conclude: “Linking poor glycemic control to expected mortality in such a quantitative manner can encourage clinicians and people with diabetes and poor glycemic control to step up their efforts to achieve the goals. Communicating the years of life lost from now on to patients at the time of consultation Working with health professionals and through messages published to patients by stakeholders such as Diabetes UK and other national / international organizations will be of great help in disseminating the conclusions of this study. More work is needed to understand why women lose more life years than men. ”
Diabetes cuts life expectancy in the UK by 6 million years
Quote: The average person with type 1 diabetes will live 8 years less and those with type 2 diabetes 2 years less: Study (2020, September 22), accessed September 22, 2020 from https://medicalxpress.com / news / 2020-09-average -person-diabetes-years.html
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