(HealthDay) – Adults with psoriatic disease are more likely to develop fractures, although they are not at increased risk of osteoporosis. This comes from an online review published November 19 in the Journal of Clinical Medicine.
Dr. Tai-Li Chen from Hualien Tzu Chi Hospital in Taiwan and colleagues examined bone mineral density (BMD) and the risk of osteoporosis and fractures in patients with psoriatic diseases, including cutaneous psoriasis and psoriatic arthritis, in a systematic review and meta-analysis. Data were drawn from published observational studies and the random effects model was used to perform the meta-analysis.
The researchers observed no significant difference between patients with psoriatic disorders and non-psoriasis controls in terms of the standardized mean difference in absolute BMD at the lumbar spine, femoral neck, or entire hip. In the combined results of the adjusted odds ratios, no increased risk of osteoporosis was found in patients with psoriasis. The odds ratio for developing bone fractures was increased in patients with psoriasis (adjusted odds ratio, 1.09).
“Our results suggest that patients with psoriatic disease may be more likely to develop fractures compared to non-psoriatic controls. This higher risk of fractures may not necessarily be associated with a lower BMD or a higher risk of osteoporosis,” the authors write. “Based on our findings, we propose that preventive measures against fractures in current clinical practice may be beneficial for such patients.”
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