Mammograms show a normal breast (left) and a breast with cancer (right). Credit: Public Domain

A study by researchers at Queen Mary University in London shows that bone loss, known to be associated with the use of the breast cancer preventive anastrozole, is partially reversed after treatment is stopped, particularly in the lumbar spine.

Anastrozole is a hormone treatment recommended by NICE for the prevention of breast cancer in high-risk women after menopause.

The results, published in the British Journal of Cancer, come from a sub-study of 1,410 women from the International Breast Cancer Intervention Study (IBIS-II), which looked at bone density in women who had completed anastrozole treatment.

After seven years, two years after women stopped taking treatment, the study found that those with weakened bones had increased bone density in the lumbar spine. The rise did not occur on the entire hip. The results suggest that the decreased bone mineral density due to the anastrozole treatment improves after the anastrozole treatment is stopped.

Lead author Ivana Sestak of Queen Mary University in London said, “Overall, the bone loss associated with anastrozole appears to be manageable. Any risk to bone health should be weighed against the overall effectiveness and tolerability of preventive treatment for high-risk women, as is known Doctors and women authorized to use this medicine will help to get a full picture of its effects so that the risks and benefits can be discussed in the decision-making process. ”

IBIS-II Study Shows Anastrozole Lowers Breast Cancer Rates In High Risk Women After Menopause

More information:
“Out-of-treatment changes in bone mineral density in postmenopausal women who received anastrozole for 5 years: 7-year results of the IBIS-II prevention study”. Ivana Sestak, Glen Blake, Raj Patel, Jack Cuzick, Anthony Howell, Robert Coleman and Richard Eastell. Br J Cancer 2021. DOI: 10.1038 / s41416-020-01228-2 Provided by Queen Mary, University of London

Quote: Anastrozole’s loss of bone density is partially reversed after the end of treatment (2021, January 22), accessed on January 22, 2021 from https://medicalxpress.com/news/2021-01-bone-density-loss-anastrozole- partially.html

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