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In a recent study, most patients with kidney failure who underwent hemodialysis developed a significant antibody response after vaccination with the Pfizer BioNTech vaccine for COVID-19, but it was significantly lower than that of those without kidney disease. The results will be published in an upcoming issue of CJASN.

People with kidney failure who receive dialysis treatments are at greater risk of severe COVDI-19 if they become infected with the virus that causes the disease. Therefore, vaccination can be particularly important for these patients. However, they also tend to develop reduced immune responses to infections and vaccinations. To assess their reactions to the COVID-19 vaccination, a team led by Dr. Moshe Shashar (Laniado Hospital and Tel-Aviv Medical Center, Israel) reported the antibody responses after vaccination with the Pfizer BioNTech vaccine in 56 patients on maintenance hemodialysis compared to 95 healthcare workers.

All health care workers developed a positive antibody response to the virus that causes COVID-19, compared to 96% of participants in the dialysis group. Average antibody levels in dialysis patients were significantly lower than in healthcare workers. There was also a significant inverse correlation between age and antibody levels in both groups.

Although the results are preliminary and require further clarification and review, they suggest that vaccination doses and schedules for COVD-19 should be reconsidered for those with kidney failure who are on dialysis.

“I believe our results should encourage dialysis-treated patients with kidney failure to get vaccinated as soon as vaccination is available for them, while we, as caregivers, should look for ways to improve its effectiveness in our patients “said Dr. Shashar.

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More information:
“Humoral Response to Pfizer BNT162b2 Vaccine in Patients Undergoing Maintenance Hemodialysis,” DOI: 10.2215 / CJN.03500321, provided by the American Society of Nephrology

Quote: The study examines the antibody response to COVID-19 vaccination in patients with kidney failure (2021, April 6th) posted on April 6th, 2021 from https://medicalxpress.com/news/2021-04-antibody-response- covid-vaccination-patients. html

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