In their clinical trials, the Pfizer and Moderna vaccines were fine, allowing the FDA to clear the emergency. In a real-world study with all participants on the front lines battling Covid, the vaccines were found to be 90% effective against the virus – not just the symptomatic disease. In the clinical trials, Pfizer and Moderna tested against diseases.

According to the CDC-sponsored study published today, it didn’t matter which vaccine participants received. What mattered was that both vaccines were developed using messenger RNA to fight off the coronavirus. The results showed that the vaccines were effective even against asymptomatic viruses.

Messenger RNA, or mRNA, carries instructions into a cell to explain how they’re supposed to work. With vaccines, the target for the message is the spike protein. This protein has three functions: it recognizes the virus, allows it to attach to the virus and then enables it to enter the cell. As soon as this happens all viral hell breaks loose. But with the vaccines, the messenger gives instructions to produce antigens, the molecules that tell the immune system to recognize an invading force. This allows the body to recognize and attack the spike protein in actual SARS-CoV-2 viruses when a person comes in contact with them.

And apparently you realize what they’re doing.

Wanting to know how the mRNA vaccines work in the real world, the CDC enrolled 3,950 people from six states – healthcare workers, first responders, and others. The 13-week study ran from mid-December to mid-March.

The vaccines were good even with just one shot, although both types usually require two shots for a full regimen. In the study, the risk of infection decreased by 80% two weeks after the first dose of vaccine.

Participants submitted their own nasal swabs for testing each week. Almost 11% of the infected infections were asymptomatic. Almost 60% of infections were discovered before the infected person developed symptoms. A total of 205 people had diagnosed infections. It is worth noting that 69% of those surveyed did not have any chronic illnesses. About 1,200 had more than one.

The study found that those infected were mostly male, Spanish first responders. The states with the most cases were Texas, Florida, and Arizona.

“The study shows that these two mRNA vaccines can reduce the risk of all SARS-CoV-2 infections, not just symptomatic infections,” said a CDC press release.